Sibutralean is indicated for the management of obesity, including weight loss and maintenance of weight loss, and should be used in conjunction with a reduced calorie diet. Sibutramine is recommended for obese patients with an initial body mass index.
Sibutralean hydrochloride (HCL) is a selective serotonin and noradrenaline re-uptake inhibitor. Obesity management is the main medical use of sibutramine. This is not a rapid acting drug. In other words, it works rather slow and in a safe manner. This leads to a steady reduction in fat mass. Longer-term results can be maintained. This drug is most effective in conjunction with a low-calorie diet and training program.
Sibutralean reduces body fat via two very distinct and effective mechanisms. Firstly, it suppresses the appetite. Studies have shown people decrease their calorie intake with as much as 1300 calories a day. Secondly, Sibutralean stimulates metabolism and daily caloric expenditure. A single tablet of 30 mg sibutramine has shown an increase in basal metabolic rate by up to 30%. This increase in metabolic rate usually lasts up to six hours from taking the capsule.
Sibutramine has a thermogenic action that happens in the adrenergic system. This happens mainly through the indirect support of beta 3-receptor activation. With Sibutralean we mainly see strong increases in brown adipose tissue thermogenesis (BAT). This increases the body temperature by 0.5 to 1 degree Celsius. As soon as the body temperature increases it is a clear indication that thermogenesis has been triggered. This means that burning is now taking place.